HALF-LIFE: 2-3 hours
METABOLISM: Primarily by CYP3A4
STARTING DOSE: 5mg PO TID
TARGET DOSING RANGE: 5mg-20mg PO TID
BEST TIME TO DOSE: Any
HOW TO DOSE:
> Initial 5mg PO TID
> Increase by increments of 5mg/day every 3 days
> Target dosing range 20mg-30mg/day
> Many patients tolerate and benefit from higher doses
> Max dose 20mg PO TID
PREGNANCY: Minimal data on safety.
BREASTFEEDING: Minimal data on safety.
- Generalized Anxiety Disorder
Off Label Uses: Reduce Sexual Side Effects of SSRIs, Drug Dependence, OCD, Adjunct for Depression
Mechanism of Action
- Partial agonist at postsynaptic 5HT-1A receptors (Increases serotonin neurotransmission to the temporal lobe)
What is buspirone (Buspar) used to Treat?
- Buspirone (Buspar) is used to treat anxiety and is approved by the Food and Drug Administration (FDA) to treat Generalized Anxiety Disorder
- In controlled trials, Buspirone (Buspar) has only demonstrated efficacy for the treatment of Generalized Anxiety Disorder
- Buspirone (Buspar) is used “off-label” to treat a variety of other psychiatric disorders such as Obsessive Compulsive Disorder, Panic Disorder, Post Traumatic Stress Disorder, and Depression.
- Buspirone (Buspar) is also used as an add-on medication (called augmentation) for depression.
- When used as an add-on medication, the purpose of adding on Buspirone (Buspar) may be to “boost” another medication such as an SSRI (e.g. sertraline, fluoxetine, escitalopram) or reduce side effects
How does Buspirone (Buspar) work?
- Serotonin is an important molecule within the brain that has many roles, including regulation of mood
- Buspirone (Buspar) boosts serotonin in important areas of the brain by mechanisms that are still poorly understood
How long does it take for Buspirone (Buspar) to work?
- While everyone is different, it usually takes 2-6 weeks for the medication to work
Do I have to take Buspirone (Buspar) everyday?
- Buspirone should be taken consistently every day as prescribed by your physician
- Buspirone is not an “as needed” medication
Is Buspirone (Buspar) Addictive?
- No. Buspirone does not induce tolerance or dependence and is not considered to have addictive potential
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