HALF-LIFE: 21-54 hours STARTING DOSE: 5mg-10mg PO daily TARGET DOSING RANGE: 10mg-20mg PO daily BEST TIME TO DOSE: Bedtime HOW TO DOSE: >> Initial 5mg-10mg PO daily >> Increase dose by 5mg per day each week to target dose of 10mg-20mg per day >> Max approved dose 20mg/day (some patients may require up to 60mg/day) >> For Bipolar depression: Initial 6mg/25mg PO QHS Increase to target dose range of olanzapine (6mg-12mg) / Fluoxetine (25mg-50mg) PO daily PREGNANCY: Minimal data on safety. BREASTFEEDING: Minimal data on safety. FDA INDICATIONS: 1) Schizophrenia, 13yo and older 2) Bipolar mania (monotherapy and adjunctive), 13yo and older 3) Bipolar maintenance (monotherapy) 4) Acute agitation in schizophrenia or bipolar (Intramuscular formulation only) 5) Bipolar depression (with fluoxetine*), 13yo and older 6) Treatment resistant unipolar depression (with fluoxetine*) *Olanzapine-Fluoxetine combination = Symbyax)
ADDITIONAL INFORMATION
Formulations: PO, IM
PO: Tablet or Orally Disintegrating Tablets (ODT, zydis)IM: Intramuscular and Depot (relprevv) injections available
Olanzapine has been studied and found helpful for chemotherapy induced nausea and vomiting
Improvement in mood in Schizophrenia, Bipolar, and Refractory depression hypothetically due to effects at 5HT2C, 5HT7, and α2 receptors.
Olanzapine + Fluoxetine have possibly synergistic antidepressant effects due to both targeting 5HT2C receptors
Dose related EPS risk
Low risk for prolactin elevation
Sedation (dose dependent) is common due to antagonism at M1, H1, and α1 receptors
Dry mouth (dose related) is common
Weight gain is common due antagonism at H1 and 5HT2C receptors
10-30 lbs weight gain common
Low risk for QTc prolongation
High cardio-metabolic risk (↑triglycerides, insulin resistance)
Orally disintegrating tablets (ODT, zydis) may reduce potential for weight gain
Metabolized by CYP1A2 and, to a lesser extent, CYP2D6
Also metabolized by direct glucuronidation (Phase II)
References:
Cooper, J. R., Bloom, F. E., & Roth, R. H. (2003). The biochemical basis of neuropharmacology (8th ed.). New York, NY, US: Oxford University Press.
Iversen, L. L., Iversen, S. D., Bloom, F. E., & Roth, R. H. (2009). Introduction to neuropsychopharmacology. Oxford: Oxford University Press.
Puzantian, T., & Carlat, D. J. (2016). Medication fact book: for psychiatric practice. Newburyport, MA: Carlat Publishing, LLC.
J. Ferrando, J. L. Levenson, & J. A. Owen (Eds.), Clinical manual of psychopharmacology in the medically ill(pp. 3-38). Arlington, VA, US: American Psychiatric Publishing, Inc.
Schatzberg, A. F., & DeBattista, C. (2015). Manual of clinical psychopharmacology. Washington, DC: American Psychiatric Publishing.
Schatzberg, A. F., & Nemeroff, C. B. (2017). The American Psychiatric Association Publishing textbook of psychopharmacology. Arlington, VA: American Psychiatric Association Publishing.
Stahl, S. M. (2014). Stahl’s essential psychopharmacology: Prescriber’s guide (5th ed.). New York, NY, US: Cambridge University Press.
Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY, US: Cambridge University Press.
Whalen, K., Finkel, R., & Panavelil, T. A. (2015). Lippincotts illustrated reviews: pharmacology. Philadelphia, PA: Wolters Kluwer.
