HALF-LIFE: Aripiprazole 74 hours; Active metabolite 94 hours
STARTING DOSE: 2mg-15mg daily
TARGET DOSING RANGE: 2mg-30mg PO daily
BEST TIME TO DOSE: Any
HOW TO DOSE:
>> Schizophrenia and mania: Initial 10mg-15mg PO daily
Max dose 30mg PO daily
>> Adjunct for depression: Initial 2mg-5mg PO daily. Increase
dose by 5mg per day at intervals of >1 week
Max dose 15mg PO daily
>> Autism and Tourette’s disorder: Initial 2mg PO daily. Increase
dose by 5mg/day at intervals of >1 week
Max dose 10mg-15mg PO daily
PREGNANCY: Minimal data on safety
BREASTFEEDING: Minimal data on safety
1) Schizophrenia, 13yo and older
2) Acute mania/mixed episodes, 10yo and older
3) Bipolar maintenance
4) Adjunct for Unipolar depression
5) Autism-related irritability, 6-17yo
6) Tourette’s disorder, 6-18yo
7) Acute agitation associated with schizophrenia or bipolar disorder (IM)
- Partial agonist at D2 receptor
- 5HT2A affinity less than D2 affinity
- 5HT1A partial agonist actions more potent than 5HT2A antagonist actions
- Usually not sedating (lacks M1 and H1 antagonism)
- Minimal weight gain, rare dyslipidemia, rare insulin resistance (except in some children and adolescents)
- Minimal to no QTc prolongation
- Antidepressant actions partially explained by 5HT1A partial agonism and 5HT7 antagonism
- Akathisia common
- Lower doses may be more activating than higher doses
- Monitor for compulsive behaviors (such as gambling) with Abilify
- Metabolized by CYP2D6 and CYP3A4
- Long acting depot formulations available
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