Olanzapine (Zyprexa)

 

HALF-LIFE: 21-54 hours
STARTING DOSE: 5mg-10mg PO daily
TARGET DOSING RANGE: 10mg-20mg PO daily
BEST TIME TO DOSE: Bedtime
HOW TO DOSE:
>> Initial 5mg-10mg PO daily
>> Increase dose by 5mg per day each week to target dose of 10mg-20mg per day
>> Max approved dose 20mg/day (some patients may require up to 60mg/day)
>> For Bipolar depression:
Initial 6mg/25mg PO QHS
Increase to target dose range of olanzapine (6mg-12mg) / Fluoxetine (25mg-50mg) PO daily
PREGNANCY: Minimal data on safety.
BREASTFEEDING: Minimal data on safety.

 

FDA INDICATIONS:
1) Schizophrenia, 13yo and older
2) Bipolar mania (monotherapy and adjunctive), 13yo and older
3) Bipolar maintenance (monotherapy)
4) Acute agitation in schizophrenia or bipolar (Intramuscular formulation only)
5) Bipolar depression (with fluoxetine*), 13yo and older
6) Treatment resistant unipolar depression (with fluoxetine*)

*Olanzapine-Fluoxetine combination = Symbyax)

 

Additional Information

  • Comes in a Tablet or Orally Disintegrating Tablets (ODT, zydis), Intramuscular injection, and Depot (relprevv) injection
  • Olanzapine has been studied and found helpful for chemotherapy induced nausea and vomiting
  • Improvement in mood in Schizophrenia, Bipolar, and Refractory depression
  • Olanzapine + Fluoxetine have possibly synergistic antidepressant effects
  • Dose related risk for extrapyramidal symptoms (e.g., dystonia, parkinsonism)
  • Low risk for prolactin elevation
  • Sedation (dose dependent) is common 
  • Dry mouth (dose related) is common
  • Weight gain is common (10-30 lbs weight gain common)
  • Low risk for QTc prolongation
  • High cardio-metabolic risk (↑triglycerides, insulin resistance)
  • Orally disintegrating tablets (ODT, zydis) may reduce potential for weight gain

References

  1. Cooper, J. R., Bloom, F. E., & Roth, R. H. (2003). The biochemical basis of neuropharmacology (8th ed.). New York, NY, US: Oxford University Press.
  2. Iversen, L. L., Iversen, S. D., Bloom, F. E., & Roth, R. H. (2009). Introduction to neuropsychopharmacology. Oxford: Oxford University Press.
  3. Puzantian, T., & Carlat, D. J. (2016). Medication fact book: for psychiatric practice. Newburyport, MA: Carlat Publishing, LLC.
  4. J. Ferrando, J. L. Levenson, & J. A. Owen (Eds.), Clinical manual of psychopharmacology in the medically ill(pp. 3-38). Arlington, VA, US: American Psychiatric Publishing, Inc.
  5. Schatzberg, A. F., & DeBattista, C. (2015). Manual of clinical psychopharmacology. Washington, DC: American Psychiatric Publishing.
  6. Schatzberg, A. F., & Nemeroff, C. B. (2017). The American Psychiatric Association Publishing textbook of psychopharmacology. Arlington, VA: American Psychiatric Association Publishing.
  7. Stahl, S. M. (2014). Stahl’s essential psychopharmacology: Prescriber’s guide (5th ed.). New York, NY, US: Cambridge University Press.
  8. Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY, US: Cambridge University Press.
  9. Whalen, K., Finkel, R., & Panavelil, T. A. (2015). Lippincotts illustrated reviews: pharmacology. Philadelphia, PA: Wolters Kluwer.